Title:

Evaluation of the usefulness of plasma renin activity determination in the selection of optimal antihypertensive therapy among patients with primary hypertension according to the Laragh and Alderman concept

Author:

Pizoń, Tomasz

Subject:

renin-angiotensin-aldosterone system ; plasma renin activity ; serum lipids ; arterial hypertension ; asymptomatic organ damage

Abstract:

The effectiveness of treatment of hypertension is low. The guidelines can be supplemented with "pathophysiological approach" to an individualized therapy.The objectives:-examination of the relationship between plasma renin activity (PRA), aldosterone and asymptomatic organ damage (AOD)-exploring the effect of antihypertensive treatment, consistent with Laragh and Alderman hypothesis, on blood pressure and AOD-evaluation of clinical and biochemical discrepancies among patients from low-renin and high-renin groups with particular reference to the values of serum lipidsOperating range: a planned prospective trial that included a total of 95-122 patients with first or second-degree hypertension.Conclusions:-the study of the effect of the renin-angiotensin-aldosterone system (RAAS) on the occurrence of AOD should include the relationship between the concentration of aldosterone and renin-PRA as the only indicator has no predictive value for the occurrence of AOD, on the other hand an aldosterone-to-renin ratio (ARR) does have it-the choice of antihypertensive drug based on PRA does not determine either the magnitude of the blood pressure reduction nor thesignificance of the AOD regression-patients with high-renin hypertension are characterized by higher serum total cholesterol and LDL-cholesterol, but the relationship between LDL-cholesterol and PRA is only in the low-renin group.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Rajzer, Marek

Date:

2019

Date issued:

2018

Type:

Praca doktorska

Call number:

ZB-130875

Language:

pol; eng

Access rights:

tylko w bibliotece