Wyszukiwanie zaawansowane ?

Obiekt

Interaction between the immune system and bone tissue

Tytuł: Interaction between the immune system and bone tissue

Autor:

Guła, Zofia

Data:

2019

Typ:

Praca doktorska

Abstrakt:

Aim: The aim of this dissertation was to explore the influence of immune system on pathogenesis of spondyloarthritis (SpA), with special consideration to eripheral blood mononuclear cells (PBMC) and the role of vitamin D. Material and methods: Research was performed both on the basis of Polish Spondyloarthritis Initiative (PolSPI) and as a part of project supported by National Centre of Science which is concerned to the role of peripheral blood mononuclear cells in bone remodeling in spondyloarthritis. Results: We found that patients with peripheral SpA have decreased number of circulating nonclassical monocytes in comparison with controls and that there is a significant negative correlation between the concentration of nonclassical monocytes and DAS28 and the number of swollen joints. In a group of axial SpA patients, sera levels of soluble RANKL were significantly lower and M-CSF, IL-6, OSM, IL-17A and TNFα significantly higher in comparison to controls. Monocytes isolated from healthy donors, cultured in the presence of sera from axSpA patients had significantly higher differentiation to osteoclast compared to monocytes cultured in sera of healthy donors.We didn’t observed correlation between concentration of vitamin D and activity of SpA when assessing disease activity scores (BASDAI, ASDAS), inflammatory markers (CRP, ESR) and clinical manifestation (peripheral arthritis, enthesitis, dactylitis). These results didn’t change after adjustment for seasonal variation and supplementation of vitamin D. Conclusions: Our research indicates significant role of non-classical monocytes in the pathogenesis of SpA, especially in peripheral arthritis. Monocytes differentiation into osteoclasts is mediated not only by RANKL stimulation (canonical pathway) but also by other soluble factors such as IL-6, OSM, IL-17A and TNFα (non-canonical pathway) which sensitize osteoclasts for RANKL stimulation. The influence of vitamin D in recommended concentration on immunological processes in SpA seems to be of little importance.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

choroby narządów ruchu

Instytucja nadająca tytuł:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promotor:

Mariusz Korkosz

Data wydania:

2019

Format:

application/pdf

Identyfikator:

oai:dl.cm-uj.krakow.pl:4341

Sygnatura:

ZB-130614

Prawa dostępu:

nieograniczony

Lokalizacja oryginału:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Temat i słowa kluczowe:

Spondyloathritis inflammation osteporosis osteogenesis

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

17 lis 2020

Data dodania obiektu:

23 cze 2020

Liczba wyświetleń treści obiektu:

60

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/4342

Wyświetl opis w formacie RDF:

RDF

Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-130614 17 lis 2020

Obiekty

Podobne

Interaction between the immune system and bone tissue

Guła, Zofia

2019
Praca doktorska

Hydroxyapatite/polylactide composite material in the healing model of bone defects in rabbits

Myciński, Paweł

2013
Praca doktorska

Macro- and microvascular endothelial dysfunction in young patients with rheumatoid arthritis and axial spondyloarthropathy without classical cardiovascular risk factors : patient phenotype and factors influencing the development of endothelial dysfunction

Nowakowski, Jarosław

2024
Praca doktorska

The influence of simvastatin on inflammatory markers in patients with chronic obstructive pulmonary disease

Kaczmarek, Przemysław

2009
Praca doktorska

Impact of administration of warfarin on development and course of ischemia/reperfusion-induced acute pancreatitis

Maduzia, Dawid

2021
Praca doktorska

Development of a new method of osteogenesis imperfecta treatment with the use of autologus mesenchymal stem cells transduced with AAV viral vector containing an inactivating cassette for the mutated collagen type I gene

Bobis-Wozowicz, Sylwia

2010
Praca doktorska

Impact of warfarin administration on development and course of experimental cerulein - induced acute pancreatitis

Konarska-Bajda, Katarzyna

2023
Praca doktorska

Markers of inflammation after myocardial infraction

Marcinkowski, Marcin

2004
Praca doktorska
Więcej
×

Cytowanie

Styl cytowania:

Dane kontaktowe

Adres

Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

Telefon

12 658 72 56
517 385 669

E-Mail

Oddział Gromadzenia i Opracowania Zbiorów
cyfrowabm@cm-uj.krakow.pl

Odwiedź nas!

Ta strona wykorzystuje pliki 'cookies'. Więcej informacji