Object
Title: Evaluation of physicochemical properties and pharmacokinetics of new compounds, derivatives of anthracycline antibiotics
Abstract:
Anthracycline antibiotics are a class of drugs used in cancer chemotherapy. Unfortunately, they are characterized by serious side effects, particularly life-threatening cardiotoxicity. For this reason, many scientists are looking for new anthracycline derivatives, which would have similar efficacy but reduced toxicity. The biological activity of anthracycline antibiotics, their uptake by cancer cells and transport in the organism are dependent on physicochemical properties, such as, pKa and logP. In addition to physicochemical properties, also pharmacokinetic profile is extremely important for the future of the compound, therefore, the key point to selecting potential drug candidates is to determine, at the initial stage of testing, their physicochemical properties and pharmacokinetic profile. During the conducted studies new bioanalytical methods using capillary zone electrophoresis and microemulsion elecrokinetic capillary chromatography were developed. First method allowed to determine pKa values, whereas second were used to determine logDpH10 of tested compounds. In the next step new methods using ultra-efficient liquid chromatography in combination with tandem mass spectrometry were created and validated. These methods were used to determine the concentration of new anthracycline antibiotics in the mice plasma in order to assess the pharmacokinetic profiles of new compound ; s after cassette dosing.
Place of publishing:
Level of degree:
Degree discipline:
Degree grantor:
Promoter:
Date issued:
Identifier:
Call number:
Language:
Access rights:
Object collections:
Last modified:
Jun 26, 2023
In our library since:
Jun 3, 2020
Number of object content hits:
86
Number of object content views in PDF format
82
All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/4315
Show description in RDF format:
Show description in OAI-PMH format:
| Edition name | Date |
|---|---|
| ZB-131394 | Jun 26, 2023 |
Objects
Similar
Matyjaszczyk-Gwarda, Karolina
Przejczowska-Pomierny, Katarzyna
Jamrozik, Marek Andrzej
Tylutki, Zofia
Bielecka, Zofia
Patel, Nikunjkumar
