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Title: Prognostic significance of mean platelet volume and its genetic variants in Polish patients with ischemic stroke

Author:

Miller, Małgorzata Maria

Date:

2019

Type:

Praca doktorska

Abstract:

Increased mean platelet volume (MPV) is a marker of worse outcome in cardiovascular disorders. The aim of the study was to determine whether MPV and single nucleotide polymorphisms (SNPs) associated with MPV in genome-wide association studies (GWAS) can be prognostic markers in patients with acute ischemic stroke. Demographic, clinical and laboratory data was collected in 577 patients with first-ever ischemic stroke. Genotyping of three SNPs (rs342293, rs1354034 and rs7961894) was performed in all subjects using a real-time polymerase chain reaction allelic discrimination TaqMan 7900 assay. Among three tested SNPs only rs7961894 was independently associated with MPV in patients with acute ischemic stroke and allele T of rs7961894 remained an independent marker of a lower one-year mortality after ischemic stroke (HR=0,27; 95%CI:0,09-0,77; p=0,014). MPV was not associated with one-year mortality in patients with ischemic stroke, however MPV ≥11,6fl was independently associated with a worse stroke severity based on National Institutes of Health Stroke Scale (NIHSS) score on admission in the studied population (OR=1,68; 95%CI:1,05-2,68; p=0,031). MPV and rs7961894 were not associated with functional independence assessed by modified Rankin Scale or activity of daily living assessed by Barthel Index on discharge in the studied population.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

neurologia ; genetyka

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Słowik, Agnieszka

Date issued:

2019

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4306

Call number:

ZB-130613

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Subject and keywords:

mean platelet volume stroke

Object collections:

Last modified:

Feb 5, 2021

In our library since:

Mar 23, 2020

Number of object content hits:

1

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4307

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Edition name Date
ZB-130613 Feb 5, 2021

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