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Title: Clinical significance of disorders associated with degenerative aortic stenosis


Aortic stenosis is the most common valvular disease in the European adult population, and the main cause of its formation is degeneration of the valve with its secondary calcification. Frequency of disease increases with age, which predisposes to co-occurrence of stenosis with other disorders.In the first article, we identified depressed eGFR (estimated glomerular filtration rate) as a strong determinant of circulating Galectin-3 (Gal-3) levels in patients with symptomatic degenerative aortic stenosis referred for invasive treatment. In the study group as a whole, Gal-3 weakly predicted total mortality, nevertheless, the effect was abolished upon adjustment for eGFR. However, multivariate-adjusted pre-procedural Gal-3 was associated with worse survival regardless of the degree of renal dysfunction in aortic stenosis subjects undergoing BAV.In the second work of the cycle, our principal finding was a lack of differences in the prevalence of traditional atherosclerotic risk factors as well as coexistent coronary and carotid atherosclerosis according to the degree of stenosis severity within patients with severe aortic stenosis.The third publication demonstrated the association of depressed systemic arterial compliance (SAC) with early exercise intolerance irrespective of stenosis severity or left ventricular systolic function in moderate-to-severe aortic stenosis patients.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski


Surdacki, Andrzej ; Kruszelnicka-Kwiatkowska, Olga

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pol; eng

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tylko w bibliotece

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Last modified:

Mar 13, 2023

In our library since:

Aug 29, 2019

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Edition name Date
ZB-129264 Mar 13, 2023


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