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Evaluation of fatty acids profile in patients after heart or renal transplantation

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Tytuł: Evaluation of fatty acids profile in patients after heart or renal transplantation

Autor:

Wilusz, Malgorzata

Data:

2018

Typ:

Praca doktorska

Abstrakt:

The aim of the study was to assess the fatty acids profile in phospholipid fractions, in patients after heart or kidney transplantation, depending on: the type of immunosuppressive drug, transplanted organ, metabolic disorders and kidney function. The doctoral dissertation consists of four scientific publications. The review article, contains information about the type and role of fatty acids. The study included: 23 heart transplant patients (9 treated with cyclosporine (CsA), 14 treated with tacrolimus (Tac)) and 65 kidney transplant recipients (24 treated with CsA, 41 treated with Tac). The study also included 25 healthy, non-transplanted individuals who set up control groups. The concentration of fatty acids was determined by gas chromatography. The obtained results confirm that the fatty acid profile of patients after transplantation is different than in healthy people. In addition, in patients after heart transplantation, the fatty acid profile depends on the type of immunosuppressant used. In kidney transplant patients, treated with Tac, with hyperlipidaemia, the metabolism of saturated fatty acids and n-6 acids is different than in patients without metabolic disorders. In turn, the analysis of the correlation between fatty acid concentration and eGFR, showed that fatty acids are essential for normal kidney function, and their role depends on the type of fatty acid.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

transplantologia ; biochemia

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Sztefko, Krystyna

Data wydania:

2018

Identyfikator:

oai:dl.cm-uj.krakow.pl:4294

Sygnatura:

ZB-129172

Język:

pol; eng

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

tacrolimus metabolic disorders cyclosporin A fatty acids transplantation

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

26 cze 2023

Data dodania obiektu:

30 maj 2019

Liczba wyświetleń treści obiektu:

101

Liczba wyświetleń treści obiektu w formacie PDF

101

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/4295

Wyświetl opis w formacie RDF:

RDF

Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-129172 26 cze 2023

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Adres

Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

Telefon

12 658 72 56
517 385 669

E-Mail

Oddział Gromadzenia i Opracowania Zbiorów
cyfrowabm@cm-uj.krakow.pl

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