Wyszukiwanie zaawansowane ?

Obiekt

Dostęp ograniczony

Ta publikacja jest chroniona prawem autorskim. Dostęp do jej cyfrowej wersji jest możliwy z określonej puli adresów ip.
Ta publikacja jest chroniona prawem autorskim. Dostęp do jej cyfrowej wersji jest możliwy z określonej puli adresów ip.

Tytuł: Evaluation of the safety profile of biological drugs used in the treatment of inflammatory bowel diseases

Author:

Moćko, Paweł

Date:

2018

Type:

Praca doktorska

Abstract:

Introduction: Ulcerative colitis (UC) and Crohn disease (CD) are classified as nonspecific inflammatory bowel diseases (IBDs). The aim of the study was to compare the safety profile of biologic drugs in patients with IBDs.Methods: A systematic literature search was performed using PubMed, Embase, and CENTRAL. Randomized controlled trials comparing biologic drugs used in the treatment of patients with UC (infliximab, adalimumab, golimumab, and wedolizumab) or CD (infliximab, adalimumab, wedolizumab, certolizumab pegol, and ustekinumab) with placebo were analyzed. The safety profile of biologic drugs was assessed using a network meta-analysis (NMA). The NMA was performed separately for patients with UC and CD, and generally for patients with IBDs. The study was registered on PROSPERO (CRD42016032607, CRD42016032606, CRD42015029884).Results: For most comparisons and endpoints, the NMA showed no significant differences in the rate of adverse events. A significantly higher risk of injection site reaction was showed for adalimumab compared with placebo (patients with UC) and a significant advantage of certolizumab pegol over infliximab and placebo (patients with IBDs). Conclusion: There were no significant differences in the relative assessment of these drugs or in their safety profile, as compared with placebo.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego

Degree grantor:

Wydział Nauk o Zdrowiu

Promoter:

Pilc, Andrzej ; Kawalec, Paweł

Date issued:

2017

Identifier:

oai:dl.cm-uj.krakow.pl:4290

Call number:

ZB-128494

Language:

pol; eng

Access rights:

tylko w bibliotece

Temat i słowa kluczowe:

ulcerative colitis biologic drugs Crohn disease network meta-analysis safety profile

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

17 mar 2023

Data dodania obiektu:

29 maj 2019

Liczba wyświetleń treści obiektu:

73

Liczba wyświetleń treści obiektu w formacie PDF

1

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/4291

Wyświetl opis w formacie RDF:

RDF

Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-128494 17 mar 2023

Obiekty

Podobne

Evaluation of the safety profile of biological drugs used in the treatment of inflammatory bowel diseases

Moćko, Paweł

2018
Praca doktorska

The clinical manifestation of inflammatory bowel disease (IBD) in the context of stress and other factors that may cause exacerbation of clinical symptoms

Brzozowski, Bartosz

2018
Praca doktorska

The occurrence of HLA-G antigen and selected markers of inflammation in patients with inflammatory bowel disease

Rozpondek, Piotr

2013
Praca doktorska

Association between short-chain fatty acids, selected inflammatory mediators, and intestinal barrier integrity in patients with inflammatory bowel diseases

Kaczmarczyk, Olga

2023
Praca doktorska

Economic analysis of biologic drugs in the treatment of ulcerative colitis in Poland

Stawowczyk, Ewa

2017
Praca doktorska

Changes in oral cavity in relation to chosen cytokines in saliva from patients with Crohn’s disease

Szczeklik, Katarzyna

2011
Praca doktorska

Magnetic resonance enterography and clinimetric methods in monitoring Lesniowski-Crohn disease treatment in pediatric patients

Herman, Roma

2022
Praca doktorska

Economic Evaluation of Crohn’s Disease Treatment with Vedolizumab and Ustekinumab After Failure of Tumour Necrosis Factor-alpha Antagonist

Holko, Przemysław

2022
Praca doktorska
Więcej
×

Cytowanie

Styl cytowania:

Dane kontaktowe

Adres

Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

Telefon

12 658 72 56
517 385 669

E-Mail

Oddział Gromadzenia i Opracowania Zbiorów
cyfrowabm@cm-uj.krakow.pl

Odwiedź nas!

Ta strona wykorzystuje pliki 'cookies'. Więcej informacji