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Prospects of pharmacological action of lipoic acid in the aspect of its new potential biological activity

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Tytuł: Prospects of pharmacological action of lipoic acid in the aspect of its new potential biological activity

Autor:

Bilska-Wilkosz, Anna

Data:

2018

Typ:

Praca doktorska

Abstrakt:

Lipoic acid (LA) is a drug with proven effect on pathogenetic mechanisms of diabetic polyneuropathy. Recent studies have indicated that LA can also be useful in the treatment of other disorders, including cardiologic, neurological, dermatologic and even oncologic diseases. However, the mechanism of so wide spectrum of pharmacological activities of LA is still insufficiently known. The aim of the present study was to broaden our knowledge of the mechanisms of biological action of LA delivered from exogenous sources. One of difficulties in studying the mechanisms of pharmacological action of LA is related to the fact that the effects of its action in vitro can differ from those observed in vivo. Nonetheless, in spite of many questions that still remain unanswered, the results of the present study unequivocally indicate that one of the mechanisms underlying biological activity of LA involves its participation in metabolic transformation of sulfane sulfur and hydrogen sulfide, defined as reactive sulfur species (RSS). It should be remembered that multidirectional regulatory functions of RSS are manifested mostly by changing the activity of many enzymatic and receptor proteins. Therefore, the hypothesis explaining LA efficacy in so many often remote pathological states by its effect on RSS transformations seems reliable and logically coherent.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

farmacja

Instytucja nadająca tytuł:

Wydział Farmaceutyczny

Promotor:

Włodek, Lidia

Data wydania:

2017

Identyfikator:

oai:dl.cm-uj.krakow.pl:4287

Sygnatura:

ZB-128501

Język:

pol; eng

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

lipoic acid potassium cyanide aldehyde dehydrogenase sulfane sulfur hydrogen sulfide

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

26 cze 2023

Data dodania obiektu:

29 maj 2019

Liczba wyświetleń treści obiektu:

263

Liczba wyświetleń treści obiektu w formacie PDF

188

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/4288

Wyświetl opis w formacie RDF:

RDF

Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-128501 26 cze 2023

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Adres

Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

Telefon

12 658 72 56
517 385 669

E-Mail

Oddział Gromadzenia i Opracowania Zbiorów
cyfrowabm@cm-uj.krakow.pl

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