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Title: Contribution of microvesicles in pathomechanism of diabetic retinopathy - the study of selected factors involved in angiogenesis

Author:

Tokarz, Aleksandra

Date:

2018

Type:

Praca doktorska

Abstract:

Diabetes and its complications still cause very serious health problems having social and economic impact on society. The classification of diabetes complications distinguishes two types of them: macroangiopathies and microangiopathies. Retinopathy is the most prevalent one among microangiopathies; it is the main cause of sight loss in patients who are professionally active.This study is dedicated to the evaluation of factors, potentially significant from the pathophysiological perspective, such as extracellular vesicles (EV), selected factors involved in angiogenesis namely angiopoietin-2 (Ang-2) and chemokine RANTES (RANTES), along with their receptors transferred by annexin V-positive microvesicles (MVAnnV+). The aim of this study was characteristic the number and profile of EV among diabetic patients in compare to a control group. The grade and severity of diabetic retinopathy, as well as the efficient diabetes managing were taken into consideration during analysis.The study extends the knowledge about extracellular vesicles in patients with diabetes and the expression of receptors Tie-2 and CCR5 on the surface of microvesicles presented in plasma. There is a need for further research to assess the pathophysiological role of MV and RANTES in retinopathy progression, including the effect of statins and acetylsalicylic acid therapy. Results reveal the contribution of microvesicles as new conveyors in vascular diabetic complications and may be used to propose the new model of angiogenesis in diseases progression.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

biochemia ; endokrynologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Nauk o Zdrowiu.

Promoter:

Ewa Stępień ; Iwona Szuścik

Date issued:

2018

Identifier:

oai:dl.cm-uj.krakow.pl:4284

Call number:

ZB-129297

ControlNumberVIRTUA:

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

microvesicles diabetes retinopathy RANTES angiopoietin-2

Object collections:

Last modified:

May 7, 2019

In our library since:

May 7, 2019

Number of object content hits:

9

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4285

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Edition name Date
ZB-129297 May 7, 2019

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