Advanced search ?

Object

The applicability of urinary leukotriene E4 measurement using ELISA testing as a non-invasive method for in vitro diagnosis of aspirin exacerbated respiratory disease (AERD)

Title: The applicability of urinary leukotriene E4 measurement using ELISA testing as a non-invasive method for in vitro diagnosis of aspirin exacerbated respiratory disease (AERD)

Author:

Stachura, Tomasz

Date:

2017

Type:

Praca doktorska

Abstract:

The diagnosis of aspirin exacerbated respiratory disease (AERD) is principally based on typical history. The aim of this study was to evaluate the applicability of measurement of LTE4 concentrations in urine by using ELISA method in diagnosis of AERD. In addition, an analysis of clinical and other laboratory data was carried out to verify their role in AERD diagnosis. The study comprised 3 groups of subjects over 18 years of age: patients with AERD (n = 247), patients with ATA (n = 239) and healthy subjects (n = 95). A detailed medical questionnaire was carried out with all patients. In addition subjects underwent: spirometry with reversibility test, skin prick tests with common aeroallergens, measurement of total IgE and eosinophil count in blood, as well as LTE4 concentration in urine by ELISA method. The analysis carried in this study shows that measurements of LTE4 concentrations in urine as a single parameter for AERD diagnosis has too low diagnostic value to be used in clinical practice. Next to typical history of hypersensitivity reactions to NSAIDs, the best clinical predictors of AERD diagnosis were the following parameters: symptoms caused by upper airway involvement, nasal polyps formation, frequent asthma exacerbations and bronchial obstruction.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia ; immunologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Grażyna Bochenek

Date issued:

2017

Identifier:

oai:dl.cm-uj.krakow.pl:4279

Call number:

ZB-129222

ControlNumberVIRTUA:

click here to follow the link

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

aspirin induced asthma aspirin exacerbated respiratory disease leukotrienes leukotriene E4

Object collections:

Last modified:

May 6, 2019

In our library since:

May 6, 2019

Number of object content hits:

19

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4280

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-129222 May 6, 2019

Objects

Similar

The applicability of urinary leukotriene E4 measurement using ELISA testing as a non-invasive method for in vitro diagnosis of aspirin exacerbated respiratory disease (AERD)

Stachura, Tomasz

2017
Praca doktorska

Prevalence of asthma with aspirin hypersensitivity in the adult population of Poland

Kasper, Łukasz

2007
Praca doktorska

Prostaglandins E2 and D2 and their metabolites in exhaled breath condensate in patients with asthma

Kaszuba, Marek.

2011
Praca doktorska

Eicosanoids measured in induced sputum and asthma phenotypes

Celejewska-Wójcik, Natalia

2017
Praca doktorska

The method of quantitative analysis of cysteinyl leukotrienes in urine based on mass spectrometry

Faber, Jacek

2009
Praca doktorska

Influence of leukotrien biosynthesis inhibition on heart electrical activity in patients with stable coronary artery disease

Sokołowska, Barbara

2010
Praca doktorska

Imbalance between prostaglandin E2 and cysteinyl-leukotrienes in aspirin-induced asthma

Gawlewicz-Mroczka, Agnieszka

2007
Praca doktorska

Impact of percutaneous coronary intervention on biosynthesis of cysteinyl leukotrienes in humans

Rzeszutko, Marcin

2007
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information