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Title: The clinical manifestation of inflammatory bowel disease (IBD) in the context of stress and other factors that may cause exacerbation of clinical symptoms


INTRODUCTION: Inflammatory bowel disease (IBD) represents a group of chronic diseases of the GI tract, such as Crohn's disease (CD) and ulcerative colitis (UC). The diet, genetic predisposition, the immunological alterations, microbiota and stress were shown to contribute to the pathogenesis of IBD. OBJECTIVES: The aim of the study was to evaluate patients with CD and UC during exacerbation and remission phases and to investigate factors that may affect the clinical activity of the disease, with particular focus on stress. PATIENTS AND METHODS: In order to determine the mucosal expression and tissue concentration of TNF- and IL-1β, patients underwent colonoscopy and the biopsy specimens were taken for 1) histological assessment of mucosal damage and 2) snap frozen in liquid nitrogen to examine the expression of IL-1 and TNF-. For examination the effect of stress on the course of IBD patients were subjected to psychological tests.RESULTS: The statistical significance has been demonstrated when investigating the correlation between SSZ (Style focused on the task), SSE (Style focused on emotions) and serum CRP levels. Taking into consideration the correlation between the CISS score and the inflammatory parameters in the control group, the data were statistically significant (P <0.002. In addition, there was an increase in IL-1β and TNF-α mRNA gene expression in biopsies of bowel mucosa in patients with IBD who had higher scores in the Stress Measurement Questionnaire.CONCLUSIONS: This study demonstrated that stress is an important pathogenic factor able to worsen the course of IBD as reflected by increased scores in variety of psychological questionnaires and the positive correlations with selected clinical markers of inflammation.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.


Tomasz Mach

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tylko w bibliotece

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Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

May 6, 2019

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May 6, 2019

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00 May 6, 2019


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