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Title: Selected aspects of preparation and quality assessment of orodispersible tablets

Author:

Brniak, Witold

Date:

2018

Type:

Praca doktorska

Abstract:

The aim of the study is to assess the usefulness of co-processed excipients for the preparation of ODTs with ibuprofen, ketoprofen or prednisolone, and to assess the usability of apparatus BJKSN-13 designed in the Department for determination of disintegration time of ODTs. 24 series of placebo tablets, 66 series with crystalline API and 7 series with taste masking microparticles were prepared.Based on the analysis of the properties of co-processed excipients and ODTs, it was found that all tested substances are useful for the preparation of the ODTs with direct compression method. Compression force and the kind of excipient used for tableting influenced the hardness and friability of tablets. Usefulness of Eudragit® E100 as an excipient masking the taste of prednisolone in microparticles has been demonstrated, however the tableting process of the microparticles resulted in changes of their properties.The apparatus developed in the Department for disintegration time measurement was characterized by 4 times greater precision than the pharmacopoeial apparatus and high repeatability of measurements. Its use allowed the analysis of disintegration time in condition similar to in vivo.Based on the designed prioritization matrix, the highest usability of Pharmaburst® was demonstrated. One year stability studies in 25°C/60%RH did not revealed any change in the properties of tablets.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmacja

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Jachowicz, Renata

Date issued:

2018

Identifier:

oai:dl.cm-uj.krakow.pl:4268

Call number:

ZB-129298

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

co-processed excipients taste masking disintegration time orodispersible tablets microparticles

Object collections:

Last modified:

Mar 13, 2023

In our library since:

Apr 26, 2019

Number of object content hits:

7

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4269

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Edition name Date
ZB-129298 Mar 13, 2023

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