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Title: Comparison of functional status of patients with ankylosing spondylitis treated with TNF-α inhibitor therapy or with methotrexate therapy
Abstract:
Aim: The aim of this study was to compare the effects of functional status of patients with ankylosing spondylitis subjected to anti-cytokine therapy or to methotrexate (MTX) therapy during six months of observation.Methods: The study included 87 patients with AS. All patients in both groups were evaluated at three times: baseline, after 3 and 6 months. BASDAI (Bath AS Functional Index), BASFI (Bath AS Functional Index) and self-service questionnaire at home and abroad were used to assess the clinical condition of the patients. Otto test, Schöber test, finger-floor test, chest extension test were used to assess global spine mobility. Mennell test and Patrick test were used for assessment of hip and sacroiliac joints function.Results: Six months after the treatment, mean BASDAI index of the MTX group was 5.46 ± 1.16 and it appeared significantly (p<0,001) higher than that of group with anti-cytokine therapy (x=4.10 ± 0.42). During follow up, BASFI was significantly (p=0.012) higher in the MTX group (x=4.9 ± 0.1) than in the anti-cytokine therapy group (x=3.3 ± 0.3) after 6 months of treatment. The improvement in thoracic spine mobility measured after six months of treatment was more visible in the group of patients subjected to anti-cytokine therapy (p<0.0001) as compared to the group receiving MTX treatment (p=0.0311). Conclusion: It could be concluded that anti-cytokine therap ; y more effectively restored physiological mobility of the spine, improved patient’s autonomy and reduced disease activity than does methotrexate therapy.
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Jaworek, Jolanta ; Zyznawska, Joanna
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Last modified:
Mar 13, 2023
In our library since:
Apr 24, 2019
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3
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http://dl.cm-uj.krakow.pl:8080/publication/4267
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| Edition name | Date |
|---|---|
| ZB-129746 | Mar 13, 2023 |
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