Title:

The significance of selected gene polymorphism related to fibrin clot formation and inflammatory process for the risk of the intracerebral haemorrhage

Author:

Jagiełła, Jeremiasz

Subject:

inflammation ; intracerebral haemorrhage ; clot ; genetics

Abstract:

The main goal of the study was to investigate the relationship between selected polymorphisms of the coagulation factors genes and inflammatory mediators genes and risk of primary intracerebral haemorrhage (PICH), according to its location, in two European populations: Polish and Greek. The following polymorphisms were analysed: FGB -455G>A, F13A1 Val34Leu, CRP +1444C>T and IL6 -174G>C. The Polish group consisted of 245 patients diagnosed with PICH and 422 healthy volunteers in the control group. The Greek group consisted of 250 patients and 250 healthy volunteers in the control group. In order to identify the analysed polymorphisms as independent risk factors for ICH the multivariate analysis was performed including those variables which distribution between the patients and healthy controls was significantly different.The association was found between polymorphisms: FGB -455G>A, F13A1 Val34Leu, CRP +1444C>T and risk of intracerebral haemorrhage in Polish population and IL6 -174G>C polymorphism and risk of intracerebral haemorrhage in Greek population.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

neurologia

Degree grantor:

Wydział Lekarski

Promoter:

Pera, Joanna

Date:

2018

Date issued:

2017

Type:

Praca doktorska

Call number:

ZB-127767

Language:

pol

Access rights:

nieograniczony