Wyszukiwanie zaawansowane ?

Obiekt

Pobierz

Tytuł: Study of the activity and expression of the enzymes involved in the formation of hydrogen sulfide in various experimental systems

Autor:

Bronowicka-Adamska, Patrycja

Data:

2017

Typ:

Praca doktorska

Abstrakt:

Apart from nitric oxide and carbon monoxide, hydrogen sulphide is another inorganic gaseous mediator. It is produced endogenously in the liver, kidneys, brain and many other human and mammalian tissues. The aim of the study were to determine the production of H2S in various tissues and cell cultures by examining the activity of the enzymes responsible for its formation and metabolism (CBS, CTH, MPST, TST) and to determine H2S levels in healthy and inflammatory tissues. A method of determination the activity of the CBS/CTH tandem in the presence of homoserine (CBS substrate) and cystathionine (CTH substrate) was developed. For the analysis of changes in cystathionine concentration the RP-HPLC method was modified. The modification also allowed for determination, during one separation, of the level GSH, GSSG, CSH, CSSC and cystathionine. The research using the developed methods allowed for defining the capabilities of different tissues (the liver, kidneys, brain) and cancer cells in the production of H2S and explained the role of H2S in the inflammation caused by stress, associated with damage to the gastric mucosa.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

biochemia

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Wróbel, Maria

Data wydania:

2017

Identyfikator:

oai:dl.cm-uj.krakow.pl:4242

Sygnatura:

ZB-128010

Język:

pol; eng

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

gastric mucosa sulfane sulfur hydrogen sulphide human brain gluthatione

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

26 cze 2023

Data dodania obiektu:

10 maj 2018

Liczba wyświetleń treści obiektu:

217

Liczba wyświetleń treści obiektu w formacie PDF

128

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/4243

Wyświetl opis w formacie RDF:

RDF

Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-128010 26 cze 2023

Obiekty

Podobne

Study of the activity and expression of the enzymes involved in the formation of hydrogen sulfide in various experimental systems

Bronowicka-Adamska, Patrycja

2017
Praca doktorska

Effect of cocaine on the metabolism of endogenous sulfur compounds in rats

Kowalczyk-Pachel, Danuta

2022
Praca doktorska

The study of L-cysteine desulfuration in mouse and human brain.Comparative studies in malignant tissues, changed by the agingprocess and cyanide poisoning

Czubak, Jerzy

2011
Praca doktorska

Prospects of pharmacological action of lipoic acid in the aspect of its new potential biological activity

Bilska-Wilkosz, Anna

2018
Praca doktorska

Anaerobic metabolism of sulfur in selected tissues of animalsexposed to lead, cadmium and mercury ions

Kaczor-Kamińska, Marta

2015
Praca doktorska

Importance of sulfane sulfur and S-thiolation reactions for modulation of biological activity of thiols

Iciek, Małgorzata

2007
Praca doktorska

The effect of cysteine desulfuration on the proliferation of normal and neoplastic brain cells

Jurkowska, Halina

2008
Praca doktorska

Hydrogen sulfide in gastroprotection of gastric mucosa against ulcerative damage induced in experimental models

Magierowski, Marcin

2016
Praca doktorska
Więcej
×

Cytowanie

Styl cytowania:

Dane kontaktowe

Adres

Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

Telefon

12 658 72 56
517 385 669

E-Mail

Oddział Gromadzenia i Opracowania Zbiorów
cyfrowabm@cm-uj.krakow.pl

Odwiedź nas!

Ta strona wykorzystuje pliki 'cookies'. Więcej informacji