Title:

Immunological response of T regulatory lymphocytes and its influence on gastrointestinal tract neoplasms development

Author:

Rubinkiewicz, Mateusz

Subject:

T regulatory lymphocytes ; precancerous states ; malignant neoplasms

Abstract:

Intoduction: The most investigated precancerous states are: Barrett’s esophagus, atrophic gastritis and colonic adenoma. It is possible to visualize infiltration of lymphocytes (TIL – tumor infiltrating lymphocytes) into the tissue of malignant tumor. Lymphocytes with the expression of foxp3+ molecule (T regulatory lymphocytes) can be found among TIL. Their role in malignancies has been proven. However, it is not known if they are present in precancerous states. Conclusions:An increase in the number of Tregs in the lymphocytic infiltration of large intestinal polyps is observed at early stages of carcinogenesis. Proportions of various T-cell subpopulations in the infiltration vary considerably depending on the degree of dysplasia, especially in case of invasive colorectal cancer. Barrett’s metaplasia, either with dysplasia or without, is associated with an evident increase in the number of Foxp3 lymphocytes within the esophagogastric junctionmucosa. Restoration of lymphocyte balance in esophageal tissue may prevent malignant transformation of Barrett’s metaplasia. Significant increase of Foxp3+ lymphocyte count and significant change of Foxp3+/CD4+ ratio are present in invasive cancer stage.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego ; onkologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Andrzej Budzyński ; Marcin Migaczewski

Date:

2017

Date issued:

2017

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-127567

ControlNumberVIRTUA:

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Language:

pol ; eng

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum