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This publication is protected and can be accessed only from certain IPs.

Title: New perspectives of molecular modeling of serotonin receptors ligands

Author:

Warszycki, Dawid

Date:

2018

Type:

Praca doktorska

Abstract:

G Protein–Coupled Receptors are the largest family of membrane proteins with over 800 members expressed in humans. Class A (rhodopsin-like) GPCRs is the largest and the best known subfamily with numerous important pharmacological targets (playing a key role, e.g., in the etiology and treatment of the nervous system diseases). Especially interesting for medicinal chemistry are serotonin receptors. This thesis presents an in silico methodologies improving the search for new serotonin receptor ligands, covering four areas of computer-aided drug design: pharmacophore mapping, homology modeling, bioisosteric replacement and fingerprint reduction.Computational methods are undeniably an essential phase in the process of designing the new drugs. The methods described in this thesis create not only new perspectives in the search for the new serotonin receptors ligands, but can be expanded to any other biological target.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmacja

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Bojarski, Andrzej J.

Date issued:

2017

Identifier:

oai:dl.cm-uj.krakow.pl:4219

Call number:

ZB-127766

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

GPCR bioisosterism pharmacophore modeling fingerprint virtual screening

Object collections:

Last modified:

Mar 14, 2023

In our library since:

Mar 16, 2018

Number of object content hits:

74

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4220

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Edition name Date
ZB-127766 Mar 14, 2023

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