Obiekt
Tytuł: Evaluation of psychotropic activity of selected indoleamine derivatives with multireceptor profile of action
Abstrakt:
Dissertation presents findings of pharmacological in vitro and in vivo studies evaluating psychotropic activity of 7 differently substituted indole derivatives. The other aim of this study was the attempt to clarify mechanism of their potential central activity, especially for ADN-2013. Aripiprazole was used as a reference atypical antipsychotic drug.In pharmacological studies in vitro, monoaminergic receptor binding profile and functional activity have been determined toward receptors D2, D3, 5-HT1A, 5-HT2A, 5-HT6, 5-HT7, α1, M and other binding sites e.g. SERT, hERG. In order to verify potential antipsychotic and cataleptogenic activity– the locomotor hyperactivity induced by D-amphetamine and MK-801 and the bar test, respectively, in mice, antidepressant activity – the forced swim test in mice and rats and the tail suspension test in mice, anxiolytic activity– the four-plate and marble burying tests in mice as well as the conflict drinking Vogel and the elevated plus-maze tests in rats were performed. Moreover, a mutagenic activity in vitro and an anorectic effect in vivo have been studied for ADN-2013. The specificity of each effect has been confirmed by appropriate control tests.The results of pharmacological studies presented confirm the desirability of searching for compounds with a multi-receptor profile of activity. ADN-2013 has been selected as a lead structure for fu ; rther research focusing on the search for more effective and safer drugs that can be used in therapy of behavioural and psychological symptoms of dementia.
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Promotor:
Wesołowska, Anna ; Kołaczkowski, Marcin
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Data ostatniej modyfikacji:
14 mar 2023
Data dodania obiektu:
15 mar 2018
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10
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http://dl.cm-uj.krakow.pl:8080/publication/4211
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| Nazwa wydania | Data |
|---|---|
| ZB-127560 | 14 mar 2023 |
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