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Title: Eicosanoids measured in induced sputum and asthma phenotypes
Abstract:
Introduction: Asthma is currently considered in terms of phenotypes, rather than of a single respiratory disease. Profiling eicosanoids in induced sputum (IS) with the means of sensitive analytical methods provides detailed information on asthmatic inflammation.Objective: In order to investigate interactions between airway inflammation and phenotypes of asthma, we integrated clinical data, IS eicosanoids and quantitative assessment of infiltrating cells into new subtypes of asthma with the means of latent class analysis (LCA).Methods: Groups of 75 AERD, 64 with aspirin-tolerant asthma (ATA) subjects and 37 healthy controls (HC) were enrolled into the study. All of them underwent sputum induction. High-performance liquid chromatography or gas chromatography coupled with mass spectrometry were used to profile eicosanoids in induced sputum supernatant (ISS).Results: Four phenotypic asthma classes were distinguished. Representing disease spectrum from mild to moderate allergic asthma with low sputum eosinophilia to severe asthma with impaired lung function, chronic rhinosinusitis, eosinophilic and neutrophilic inflammation and frequent aspirin hypersensitivity. Increased levels of lipid mediators were measured: PGA2 in class 1, cys-LTs and PGD2 in class 2 and in PGE2 in class 4. Aspirin hypersensitivity was most frequent in class 2, but also present in class 1 and 4.Conclusions: Eo ; sinophils and their mediators: cys-LTs and PGD2 were identified to have special importance in the pathophisiology of severe asthma phenotypes. This study points out the heterogenity of AERD population.
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Last modified:
Mar 16, 2023
In our library since:
Nov 7, 2017
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16
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http://dl.cm-uj.krakow.pl:8080/publication/4205
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| Edition name | Date |
|---|---|
| ZB-127028 | Mar 16, 2023 |
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