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This publication is protected and can be accessed only from certain IPs.

Title: Antiatherosclerotic mechanisms of Mas receptor stimulation by angiotensin 1-7 mimetic (AVE0991) in ApoE-/- mice

Author:

Skiba, Dominik

Date:

2017

Type:

Praca doktorska

Abstract:

The aim of the work was to characterise perivascular inflammation in the early stages of atherosclerosis and to determine how stimulation of the Mas receptor by AVE0991 affects the inflammatory mechanisms of atherosclerosis. Results showed that AVE0991 has anti-inflammatory effects on perivascular adipose tissue by reducing leukocytes content (especially macrophages, T cells, NK cells and dendritic cells) at early stage atherosclerosis. Agonism of Mas receptor by AVE0991 results in reduction of atherosclerotic plaque area and improved stability by reduction of macrophages content in atherosclerotic plaque. Anti-inflammatory effects of AVE0991 are primarily associated with decreased gene expression of pro-inflammatory and chemotactic agents in perivascular adipose tissue. Mechanism of action of AVE0991 is also associated with a reduced polarization to M1 macrophages as well as by decreased chemotaxis of pro-inflammatory monocytes.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Guzik, Tomasz

Date issued:

2016

Identifier:

oai:dl.cm-uj.krakow.pl:4195

Call number:

ZB-126812

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

atherosclerosis inflammation macrophages T cells perivascular adipose tissue

Object collections:

Last modified:

Mar 16, 2023

In our library since:

Oct 30, 2017

Number of object content hits:

13

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4196

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Edition name Date
ZB-126812 Mar 16, 2023

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