Title:

Prognostic significance of hyperfibrynogenemia in ischemic stroke patients

Author:

Swarowska-Skuza, Marta

Subject:

ischemic stroke ; fibrinogen ; outcome ; mortality ; model

Abstract:

The doctoral thesis consists of three original articles, which are thematically coherent collection of research papers that examined the prognostic significance of hyperfibrynogenemia in ischemic stroke patients. The aim of our first study was to determine if the sustained increase of plasma fibrinogen during the first two weeks after a stroke predicts outcome independently of baseline fibrinogen concentration. Results: the sustained increase of plasma fibrinogen during ischemic stroke predicts worse outcome independently of baseline fibrinogen level. The aim of our second study was to determine the relationship between plasma fibrinogen level and long-term risk of death in ischemic stroke patients. Results: hyperfibrinogenemia predicts the long-term risk of death in ischemic stroke patients. The aim of our third study was to determine the prognostic value of plasma fibrinogen for the prediction of functional outcome after ischemic stroke. Results: the addition of fibrinogen to predictive model including age and stroke severity does not improve discrimination between favorable and unfavorable outcomes after ischemic stroke.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

neurologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Tomasz Dziedzic

Date:

2017

Date issued:

2016

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-126813

ControlNumberVIRTUA:

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Language:

pol ; eng

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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