Advanced search ?

Object

Download

Title: Doxorubicin cardiotoxicity assessment in lymphoma patients in the Hematological Department, Collegium Medicum, Jagiellonian University

Author:

Sobociński, Marcin

Date:

2017

Type:

Praca doktorska

Abstract:

In this study we analyzed a group of 219 lymphoma patients treated with chemotherapy cycles containing doxorubicine. We that found that in 118 patients who were analyzed retrospectively the strongest risk factor for cardiovascular events that increases the risk of cardiotoxicity is hypertension. In the group of 101 patients who were analyzed prospectively we found early symptoms of heart failure on echocardiography in 55 (55%) of patients treated with first-line chemotherapy cycles containing doxorubicin. Moreover a higher incidence of independent systolic dysfunction (30%) and independent diastolic dysfunction (20%) was found than both of these forms occurring concurrently (5%). During an observation period of 5 years, in a comparative analysis of both groups, 20 cardiac deaths (11 sudden cardiac deaths and 9 deaths secondary to progressive heart failure) occurred in the retrospective group compared to a lack of cardiac deaths in the prospective group. Performing echocardiography and diagnosing systolic or diastolic dysfunction before treatment and after the 3 treatment cycle allowed the implementation of primary cardioprotection in the form of liposomal doxorubicin use in further cycles. There was no difference in treatment efficacy (complete remission – CR) in patients with DLBCL treated with conventional (CR 77.5%) and liposomal (CR 90%) forms of doxorubicin.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

hematologia ; choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Jurczak, Wojciech

Date issued:

2016

Identifier:

oai:dl.cm-uj.krakow.pl:4184

Call number:

ZB-126657

Language:

pol

Access rights:

nieograniczony

Subject and keywords:

diastole doxorubicin echocardiography lymphoma cardiotoxicity

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Oct 16, 2017

Number of object content hits:

284

Number of object content views in PDF format

112

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4185

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-126657 Jun 26, 2023

Objects

Similar

Doxorubicin cardiotoxicity assessment in lymphoma patients in the Hematological Department, Collegium Medicum, Jagiellonian University

Sobociński, Marcin

2017
Praca doktorska

The assessment of anthracycline-induced cardiotoxicity inlymphoma patients on the basis of own material

Kumiega, Beata

2016
Praca doktorska

Early detection of the increased risk of cardiovasculartoxicity in patients undergoing anthracycline-based CHOPregimen

Długosz-Danecka, Monika

2015
Praca doktorska

Polska Grupa Badawcza Chłoniaków

serwis informacyjny

Evaluation of dendritic cells in cutaneous lymphomas

Szpor, Joanna

2013
Praca doktorska

Assessment of the cardioprotective properties of angiotensin converting enzyme inhibitor (ACEi) among breast cancer patients

Słowik, Agnieszka J.

2019
Praca doktorska

Influence of the treatment of the selected cardiac arrhythmias by RF catheter ablation on the left ventricular systolic and diastolic function and exercise capacity

Dreher, Adam

2009
Praca doktorska

Treatment escalation in Hodgkin’s lymphoma patients due to clinical and biological risk factors

Krochmalczyk, Dorota

2011
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information