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Tytuł: Design of microemulsion dosage form throughapplication of data mining techniques

Autor:

Szlęk, Jakub

Data:

2017

Typ:

Praca doktorska

Abstrakt:

Aim of the dissertation was to evaluate the application of data mining techniques in the process of microemulsion formulation. Three main stages of the work were established: data mining and the development of the decision support system, writing a code of the computer application and validation of the system in practice.Both computational and technological methods were used to carry out the research. As a part of computational procedure following objectives have been done: the database was created which contained a numeric representation of qualitative and quantitative composition of the microemulsion, the heuristics modeling was conducted, the decision support system was developed, as well as the ME_DSS program code was written. To assess the ME_DSS prediction efficiency analysis of physicochemical properties and stability studies were made as a part of technological process. The microemulsion formulation composition was designed for dermal administration of ibuprofen as a model sparingly soluble in water drug active pharmaceutical ingredient.System included 5 neural networks and one RandomForest model. Application integrating the support system and its source code was uploaded on the sourceforge.net.Twenty microemulsion formulations were chosen to assess their physicochemical properties and stability. Similar assays were conducted for two microemulsions with drug substance.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

farmacja

Instytucja nadająca tytuł:

Wydział Farmaceutyczny

Promotor:

Jachowicz, Renata ; Mendyk, Aleksander

Data wydania:

2017

Identyfikator:

oai:dl.cm-uj.krakow.pl:4182

Sygnatura:

ZB-126654

Język:

pol

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

data mining decision support system microemulsion

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

26 cze 2023

Data dodania obiektu:

11 paź 2017

Liczba wyświetleń treści obiektu:

544

Liczba wyświetleń treści obiektu w formacie PDF

148

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/4183

Wyświetl opis w formacie RDF:

RDF

Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-126654 26 cze 2023

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Dane kontaktowe

Adres

Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

Telefon

12 658 72 56
517 385 669

E-Mail

Oddział Gromadzenia i Opracowania Zbiorów
cyfrowabm@cm-uj.krakow.pl

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