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Tytuł: Coronary flow reserve alterations related to clinical,echocardiographic and biochemical parameters after aortic valvereplacement due to severe stenosis
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The aim of study was to: 1) asses CFR in AS patients prior AVR; 2) asses prognostic value of CFR in AVR results; 3) asses CFR changes following 3AVR. Material and methods: Prospectively collected data of 36 AS patient scheduled for AVR was analysed. Coronary angiogram was done to exclude significant stenosis of epicardial arteries. CFR was measured by means of echocardiography in left anterior descending artery. Assessment was done prior AVR, 3, 6 and 12 months post AVR. Results: Pre AVR CFR was decreased [Me 1.65; (1.12; 2.17)]. Increase in CFR was observed 3 months after AVR with no changes in 6 and 12 months [2.21; (1.58; 2.83) vs. 2.23 (1.17; 3.53) vs. 2.24 (1.60; 3.76) respectively; p<0,001]. There was decreased peak diastolic velocity in resting conditions(V0) after 3 months [from 0.39 (0.26; 0.66) m/s to 0.29 (0.21; 0.52);p<0,001] and no further reduction in V0. Regarding peak diastolic velocity during hypeaemia (Vmax), significant change was observed after 6 months [from 0.62 (0.39; .82) to 0.66 (0.39; 0.98); p=0,018]. Negative correlations between CFR and mean transvalvular pressure gradient (PG mean) (r=-0.3366; p=0.0319) and peak transvalvular velocity (AV Vmax) (r=-0.3987;p=0.0086) prior AVR were observed. Conclusion: Coronary flow reserve is reduced in patients with severe aortic stenosis with no changes in coronary arteries. CFR is not useful in prediction of AVR ; results in 12 months follow up. CFR increases after AVR. Improvement of CFR was associated with decreased peak diastolic flow velocity at rest and increased velocity during maximal hyperaemia. Highest CFR improvement was observed 3 months after AVR.*
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Data ostatniej modyfikacji:
16 mar 2023
Data dodania obiektu:
23 mar 2017
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http://dl.cm-uj.krakow.pl:8080/publication/4154
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| Nazwa wydania | Data |
|---|---|
| ZB-126137 | 16 mar 2023 |
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