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Title: Coronary flow reserve alterations related to clinical,echocardiographic and biochemical parameters after aortic valvereplacement due to severe stenosis

Author:

Nosal, Marcin

Date:

2016

Type:

Praca doktorska

Abstract:

The aim of study was to: 1) asses CFR in AS patients prior AVR; 2) asses prognostic value of CFR in AVR results; 3) asses CFR changes following 3AVR. Material and methods: Prospectively collected data of 36 AS patient scheduled for AVR was analysed. Coronary angiogram was done to exclude significant stenosis of epicardial arteries. CFR was measured by means of echocardiography in left anterior descending artery. Assessment was done prior AVR, 3, 6 and 12 months post AVR. Results: Pre AVR CFR was decreased [Me 1.65; (1.12; 2.17)]. Increase in CFR was observed 3 months after AVR with no changes in 6 and 12 months [2.21; (1.58; 2.83) vs. 2.23 (1.17; 3.53) vs. 2.24 (1.60; 3.76) respectively; p<0,001]. There was decreased peak diastolic velocity in resting conditions(V0) after 3 months [from 0.39 (0.26; 0.66) m/s to 0.29 (0.21; 0.52);p<0,001] and no further reduction in V0. Regarding peak diastolic velocity during hypeaemia (Vmax), significant change was observed after 6 months [from 0.62 (0.39; .82) to 0.66 (0.39; 0.98); p=0,018]. Negative correlations between CFR and mean transvalvular pressure gradient (PG mean) (r=-0.3366; p=0.0319) and peak transvalvular velocity (AV Vmax) (r=-0.3987;p=0.0086) prior AVR were observed. Conclusion: Coronary flow reserve is reduced in patients with severe aortic stenosis with no changes in coronary arteries. CFR is not useful in prediction of AVR results in 12 months follow up. CFR increases after AVR. Improvement of CFR was associated with decreased peak diastolic flow velocity at rest and increased velocity during maximal hyperaemia. Highest CFR improvement was observed 3 months after AVR.*

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jerzy Sadowski

Date issued:

2016

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4154

Call number:

ZB-126137

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

aortic stenosis coronary circulation coronary flow reserve, aorticvalve replacement echocardiography

Object collections:

Last modified:

May 24, 2021

In our library since:

Mar 23, 2017

Number of object content hits:

5

Number of object content views in PDF format

5

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4154

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Edition name Date
ZB-126137 May 24, 2021

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