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Title: The effect of physical activity on serum levels of selected biomarkers of inflammation, endothelial function and haemostasis in athletes and nonathletes
Abstract:
The aim of the study was to assess the effects of physical activity on oxidative stress, inflammatory process, endothelial function, thrombin generation and platelets function. Sixty nine athletes and 46 age- and sex-matched nonathletes were studied. All subjects underwent maximal treadmill cardiopulmonary exercise test. Physical activity level was assessed using the International Physical Activity Questionnaire-Short Form. Blood samples were taken before and immediately after exercise. Markers of oxidative stress (8-iso-PGF2α), endothelial function (sICAM-1, ADMA), inflammatory process (IL-6, IL-10, IL-18), thrombin generation (TAT) and platelets activation (sCD40L) were determined. As compared to nonathletes, the athletes group was characterized by lower level of 8-iso-PGF2α (20.69 ± 16.29 vs. 26.72 ± 16.22 pg/ml; p=0.036), IL-6 (0.43 ± 0.31 vs. 0.86 ± 1.21 pg/ml; p=0.015), sCD40L (2091.39 ± 2446.01 vs. 3733.63 ± 4006.36 pg/ml; p=0.03). sCD40L level raised significantly at the peak of exercise in controls (3733.63 ± 4006.36 vs. 5784.05 ± 9456.25 pg/ml; p=0,045), whereas there was no significant change in athletes group (2091.39 ± 2446.01 vs. 2589.48 ± 2974.96 pg/ml; p=0.07). The study showed that the level of inflammatory process and oxidative stress indicators as well as platelets activation are lower in the competitive athletes as compared to nonathletes, which may have a b ; eneficial role in relation to the development of atherosclerotic lesions. Lower platelets activation at the peak of exercise in athletes group may to be important in the prevention of sudden cardiac death during high intensity exercise.
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Last modified:
Mar 16, 2023
In our library since:
Mar 13, 2017
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23
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All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/4138
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| Edition name | Date |
|---|---|
| ZB-125993 | Mar 16, 2023 |
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