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Title: The effect of physical activity on serum levels of selected biomarkers of inflammation, endothelial function and haemostasis in athletes and nonathletes

Author:

Karch, Izabela

Date:

2016

Type:

Praca doktorska

Abstract:

The aim of the study was to assess the effects of physical activity on oxidative stress, inflammatory process, endothelial function, thrombin generation and platelets function. Sixty nine athletes and 46 age- and sex-matched nonathletes were studied. All subjects underwent maximal treadmill cardiopulmonary exercise test. Physical activity level was assessed using the International Physical Activity Questionnaire-Short Form. Blood samples were taken before and immediately after exercise. Markers of oxidative stress (8-iso-PGF2α), endothelial function (sICAM-1, ADMA), inflammatory process (IL-6, IL-10, IL-18), thrombin generation (TAT) and platelets activation (sCD40L) were determined. As compared to nonathletes, the athletes group was characterized by lower level of 8-iso-PGF2α (20.69 ± 16.29 vs. 26.72 ± 16.22 pg/ml; p=0.036), IL-6 (0.43 ± 0.31 vs. 0.86 ± 1.21 pg/ml; p=0.015), sCD40L (2091.39 ± 2446.01 vs. 3733.63 ± 4006.36 pg/ml; p=0.03). sCD40L level raised significantly at the peak of exercise in controls (3733.63 ± 4006.36 vs. 5784.05 ± 9456.25 pg/ml; p=0,045), whereas there was no significant change in athletes group (2091.39 ± 2446.01 vs. 2589.48 ± 2974.96 pg/ml; p=0.07). The study showed that the level of inflammatory process and oxidative stress indicators as well as platelets activation are lower in the competitive athletes as compared to nonathletes, which may have a beneficial role in relation to the development of atherosclerotic lesions. Lower platelets activation at the peak of exercise in athletes group may to be important in the prevention of sudden cardiac death during high intensity exercise.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Maria Olszowska

Date issued:

2016

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4138

Call number:

ZB-125993

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

atherosclerosis endothelial dysfunction inflammation physical activity oxidative stress

Object collections:

Last modified:

May 24, 2021

In our library since:

Mar 13, 2017

Number of object content hits:

10

Number of object content views in PDF format

10

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4138

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Edition name Date
ZB-125993 May 24, 2021

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