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Title: The assessment of anthracycline-induced cardiotoxicity inlymphoma patients on the basis of own material

Author:

Kumiega, Beata

Date:

2016

Type:

Praca doktorska

Abstract:

The aim of this study was to assess of anthracycline induced cardiotoxicity in lymphoma patients. The data for32 patients was analyzed prospectively, and 62 patients underwent retrospective analysis. A 10% reduction in the ejection fraction was found for 13 out of 29 patients from prospective group and for 20 out of 62 patients from the retrospective group. Serious cardiac events were noticed in10 out of 29 patients analyzed prospectively and 13 out of 62 patients analyzed retrospectively. Significantly higher incidence of mortality independently of the direct cause was found in patients with an ejection fraction of 55% prior to chemotherapy, and an early reduction in ejection fraction after 2-4 administrations of doxorubicin to a value of 55% compared to patients with an ejection fraction > 55%.The left ventricle relaxation was abnormal for 11 out of 31 patients in the prospective group and for 9 out of 39 patients in the retrospective group. The diastolic dysfunction was more frequent in the patients with serum troponin T concentration > 0.025ng/ml and in the patients with high serum NT-proBNP concentration after the first doxorubicin treatment. Decreased PFR during the exercise test in GSPECT assessment was detected in the prospectively analyzed group of patients after chemotherapy. Decreased PFR was seen in 9 out of 12 patients when GSPECT was investigated.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia ; onkologia

Degree grantor:

Wydział Lekarski

Promoter:

Pluta, Andrzej

Date issued:

2015

Identifier:

oai:dl.cm-uj.krakow.pl:4125

Call number:

ZB-125263

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

doxorubicin cardiotoxicity lymphoma biomarkers of renal function GSPECT

Object collections:

Last modified:

Mar 15, 2023

In our library since:

Sep 22, 2016

Number of object content hits:

14

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4125

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Edition name Date
ZB-125263 Mar 15, 2023

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