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Title: Application of molecular methods to the diagnosis of invasive fungal infections and clinico-epidemiological analysis of fungal infections in hospitalized patients


The objective of the study was to analyze the epidemiological prevalence of fungal colonization/infections in patients hospitalized in selected wards of the Ludwik Rydygier Memorial Hospital in Krakow in the period from 2008 to 2012, evaluation of genetic relatedness among the most frequently isolated species of fungi and the development of molecular method, effective in diagnosing maxillary sinus infections caused by Aspergillus spp.Epidemiological analysis showed the highest isolation of fungi in Intensive Care Unit patients. The3majority of them were colonized by Candida spp, however there was also a statistically significant increase in the incidence of candidemia as well as fungal infections of the respiratory and urinary tract, which confirms that patients requiring intensive care are at high risk of developing fungal infections. The most common etiological agent of colonization/infection was C. albicans and C. glabrata, what confirms the epidemiological data from the North-Central Europe.Evaluation of the genetic relatedness between Candida strains, revealed endogenous origin of most strains. Identification of two identical C. glabrata isolates confirmed the risk of spreading the infection of exogenous origin in hospital ward.The developed nested PCR method showed high sensitivity and specificity in identifying of Aspergillus spp. in biopsies of maxillary sinus in patien ; ts with suspected sinus aspergillosis.

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2 - studia doktoranckie

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Wydział Farmaceutyczny


Budak, Alicja

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Mar 15, 2023

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Aug 24, 2016

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ZB-124658 Mar 15, 2023


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