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Title: Features of left atrium in transthoracic echocardiography and coagulation parameters among patients with atrial fibrillation in comparison to healthy persons and hypertensives


Aims of the study were assessment of activity of hemostasis in patients with permanent and paroxysmal atrial fibrillation with estimation of its differences in comparison to patients with arterial hypertension and healthy controls, and also assessment of correlations between levels of hemostatic markers and echocardiographic parameters of left atrium and left ventricle.Study population consists of patients in age 29-84 years with atrial fibrillation (AF) [43 persons with permanent AF (gPermAF) and 50 persons with paroxysmal AF (gPxAF)],arterial hypertension (47 persons, gAH) and also 18 healthy controls in age 39-60 years (g0). In study participants transthoracic echocardiography (TTE) and assessment of concentration of thrombin-antithrombin III complex, tissue factor, fibrinogen, soluble P-selectin, platelet factor-4, C-reactive protein in venous blood were performed.Differences in activity of hemostasis were seen between study groups. Correlations of some TTE parameters of left atrium and left ventricle with analyzed markers of hemostasis and inflammation were observed. These associations between parameters were stronger especially in subgroups with left ventricular diastolic dysfunction or with enlarged left atrium.Levels of activity of hemostasis are different in study groups. Some echocardiographic parameters are correlated with hemostatic markers, so it can be concluded t ; hat morphology and function of heart chambers have importance for level of activity of prothrombotic state and also inflammatory processes, especially in persons with diastolic dysfunction.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski


Czarnecka, Danuta

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tylko w bibliotece

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Last modified:

Mar 16, 2023

In our library since:

Aug 23, 2016

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Edition name Date
ZB-124954 Mar 16, 2023


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