Comparison of research results computed tomography performed locally with the central assessment of the degree of sophistication and early response to treatment of classical form of Hodgkin Lymphoma in children and adolescents in Poland
Eighty-eight patients (3–18 years of age) with cHL diagnosed within the period of 2009–2012 in 13 pediatric oncological centers in Poland were analyzed. The aim of the work was to assess the results of the computed tomography (CT) in patients with HL performed locally in terms of: technical validation of CT, imaging of the lymph node biopsy region, appointments of control lymph nodes imaging and number of the parts of body in early assessment CT scans. The results of CT imaging of local and central evaluations were compared in terms of: the interpretation of imaging tests, the stage, qualification to the therapeutic groups (TG), initial reference volumes, degree of regression of volumes after 2 cycles of chemotherapy (ChTh) and the qualification of the patient to radiotherapy (RTh). Non-compliance of the disease stage assessment in the local and central evaluation concerned 37 children. As a result of the central verification the stage of disease was increased in 26 children and decreased in 11 patients. Among the patients with decreased stage of disease, three children were qualified centrally to lower risk therapeutic group. Among the patients in whom the sate of disease was increased, the therapeutic group was changed in 11 children. Compatibility of qualifications to TG1, TG2, and TG3 therapeutic group was: 97%, 58% and 85%, respectively.On the basis of the results of CT and positron emission tomography (PET/CT) performed after two cycles of ChTh in the central verification, among 88 analyzed patients, 45 (51%) children did not require RTh and were qualified for treatment with the use of chemotherapy only.