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Title: Role of metalloproteins containing copper, zinc or iron in pathogenesis of organ changes in hypertension

Abstract:

The aim of this study was to assess the relationship between plasma trace elements concentration (iron, copper and zinc), their 24-hour urinary excretion, plasma metalloprotein concentration (ferritin, ceruloplasmin) and blood pressure (BP) values, the prevalence of hypertension and indicators of cardiac and vascular organ damage typical for hypertension. The study group included 303 individuals, recruited from the general population (138 parents; 165 offspring, 136M/167F). In addition anthropometric measures, conventional BP measurements and 24-hour ambulatory BP monitoring, echocardiography, carotid ultrasonography and arterial applanation tonometry were provided. Iron, copper and zinc plasma concentration and 24-hour urinary excretion was assessed by ICP-MS (Inductively Coupled Plasma Mass Spectrometry). Selected metalloproteins of these metals (ferritin, ceruroplasmin) were determined by the ELISA test. Database management and statistical analysis were performed with SAS software (SAS Institute, Cary, NC), version 9.3. In this study the association of iron and copper homeostasis with blood pressure (BP) values and the association of three metals under study with vascular complications were shown. The results in the future may contribute to the further research into the pathogenesis of hypertension.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Katarzyna Stolarz-Skrzypek ; Szczepan Zapotoczny

Date issued:

2015

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4061

Call number:

ZB-124230

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Apr 13, 2016

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3

Number of object content views in PDF format

3

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4061

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ZB-124230 May 24, 2021
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