Title:

A comprehensive assessment of fibrin clot structure and function in patients with atrial fibrillation taking vitamin K antagonists

Author:

Ząbczyk, Michał

Subject:

clot lysis time ; atrial fibrillation ; vitamin K antagonists ; fibrin clot ; fibrin clot permeability

Abstract:

Atrial fibrillation (AF) increases the risk of thromboembolism that is reduced by vitamin K antagonists (VKAs). Prothrombotic fibrin clot phenotype might be arisk factor for thromboembolic complications. Fibrin clot properties in patients taking VKAs have not been investigated yet. We evaluated an automated method for fibrin clot permeability (Ks) assessment, tested whether long-term treatment with VKAs affects the structure of fibrin network, and investigated changes in plasma fibrin clot phenotype at the onset of oral anticoagulation. We showed that 10 pM TF as a coagulation trigger may reflect the in vivo process from initiation of the coagulation cascade to fibrin formation in AF patients taking VKAs. Finally, we demonstrated that plasma fibrin clot properties in AF patients are favourably modified as early as after 3 days of VKA administration, which might contribute to anticoagulant and antithrombotic effectiveness.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Undas, Anetta

Date:

2016

Date issued:

2015

Type:

Praca doktorska

Call number:

ZB-124213

Language:

pol; eng

Access rights:

tylko w bibliotece