Effect of angiotensin converting enzyme inhibitors and statins on the expression of coagulation factors in the narrow aortic valves – associations with calcification, neovascularization and inflammation in aortic stenosis - Digital Medical Library

Skip to main menu
Skip to search engine
Skip to content
Skip to footer

Download

Description
Information

Title: Effect of angiotensin converting enzyme inhibitors and statins on the expression of coagulation factors in the narrow aortic valves – associations with calcification, neovascularization and inflammation in aortic stenosis

Author:

Kapusta, Przemysław

Date:

Type:

Praca doktorska

Abstract:

This dissertation presents the effect of statins, angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blocker (ARB) on the expression of proteins associated with inflammation, calcification and coagulation cascade in vitro in VICs cultures. This study presents mRNA analysis of the gene expression associated with inflammation, calcification and osteoblastic transformation, coagulation proteins, PAR receptors and a neovascularization using Real-time PCR in three different aortic valve areas. In addition, the influence of statins: atorvastatin and rosuvastatin, ACEI: enalpril and ramipril, and ARB: candesartan, in different concentrations on the expression of proinflammatory cytokines, calcification and expression of coagulation proteins and PAR receptors in stimulated VICs was analyzed. This in vitro study increases knowledge about the effect of statins, ACEIs and ARB on proinflammatory response, calcification and expression of coagulation protein in AS.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia ; farmakologia

Degree grantor:

Wydział Lekarski

Promoter:

Undas, Anetta ; Adamczyk, Zbigniew

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:4049

Call number:

Language:

Access rights:

Subject and keywords:

aortic stenosis inflammation statins angiotensin converting enzyme inhibitors coagulation

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Jun 26, 2023

In our library since:

Apr 8, 2016

Number of object content hits:

214

Number of object content views in PDF format

126

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4049

Show description in RDF format:

Show description in OAI-PMH format:

Edition name	Date
ZB-123685	Jun 26, 2023

Objects

Similar

Effect of angiotensin converting enzyme inhibitors and statins on the expression of coagulation factors in the narrow aortic valves – associations with calcification, neovascularization and inflammation in aortic stenosis

Kapusta, Przemysław

2015

Praca doktorska

New mechanisms of activation of the coagulation system in acute coronary syndromes

Szułdrzyński, Konstanty

2009

Praca doktorska

Influence of anti-inflammatory therapy on endothelial function in unstable angina

Chyrchel, Michał

2006

Praca doktorska

Impact of administration of warfarin on development and course of ischemia/reperfusion-induced acute pancreatitis

Maduzia, Dawid

2021

Praca doktorska

Relation between chronic airway inflammation, systemic activation of coagulation pathway and the cardiovascular risk in asthma

Kuczia, Paweł

2023

Praca doktorska

The role of blood coagulation in aortic stenosis and concomitant aneurysmatiuc dilation of ascending aorta

Mazur, Piotr

2019

Praca doktorska

Clinical significance of disorders associated with degenerative aortic stenosis

Bobrowska, Beata

2018

Praca doktorska

Effects of exercise stress testing on blood coagulation and fibrinolysis in aortic valve stenosis

Kolasa-Trela, Renata

2014

Praca doktorska

More

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

https://bm.cm.uj.edu.pl/en/main-page/

This page uses 'cookies'. More information