Title:

Serum and hair concentration of selected trace elements and heavy metals in children with newly diagnosed inflammatory bowel disease

Author:

Stochel-Gaudyn, Anna

Subject:

inflammatory bowel disease ; trace elements ; microelements ; mass spectrometry ; malnutrition

Abstract:

Introduction: Numerous publications indicate that up to 40% of patients with inflammatory bowel disease (IBD) develop malnutrition that may have a particular impact in developmental period and can concern both macro and microelements.Aim: To assess the serum and hair concentration of selected elements (Fe, Mn, Se, Zn, Cu, Pb) in children with IBD at diagnosis and after one year of observation.Materials and Methods: 41 children with newly diagnosed IBD and 20 healthy children were recruited. A serum and hair sample was collected for trace elements and heavy metals concentration measurement using inductively coupled plasma mass spectrometry (ICP-MS) and hydride generation atomic fluorescence spectrometry (HG-AFS).Results: In newly diagnosed children with IBD significantly less concentration in serum of iron (median: 1,09 mg/L vs 1,52 mg/L) and zinc (median: 0,78 mg/L vs 0,88 mg/L) were found (p=0,049), whereas copper was significantly greater (median: 1,38 mg/L vs 1,06 mg/L) (p<0.001) compared to control group. Mean concentration in hair of measured elements were similar in both groups. There was a correlation between concentration in serum and hair of copper in CU patients.Conclusion:1. The concentration of iron and zinc in serum of IBD children at the moment of diagnosis is less, whereas copper concentration is greater compared to the healthy controls. No significant difference was found between concentrations of examined elements in hair.2. No correlation (except copper in CU) between concentration in serum and hair of examined elements was found, thus hair as analytic material is of poor use in IBD children

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego ; pediatria

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Krzysztof Fyderek ; Paweł Kościelniak

Date:

2015

Date issued:

2015

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-123708

ControlNumberVIRTUA:

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Language:

pol

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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