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Title: Effects of cardiac resynchronisation therapy on the autonomic nervous system function, sleep disorders, and vascular stiffness


The aim of this study was simultaneous evaluation of CRT effects on the autonomic nervous system function, sleep disorders, arterial stiffness, depression level, as well as an assessment of their interactions, together with an analysis of a clinical response of all these parameters to CRT. The study covered 55 people with chronic heart failure stable for at least last 3 months, in the NYHA class III-IV despite optimal pharmacotherapy, with sinus rhythm present during the examination, a left ventricular ejection fraction (LVEF) ≤ 35%, wide QRS complexes ≥ 120 ms. In the whole group a statistically significant increase in the arterial baroreflex sensitivity (BRS) when lying and return their ability to modulate in response to orthostatic stimulus were observed. The values of apnea-hypopnea index, as well as central and mixed apnea indexes were statistically significantly reduced. A shift in dominance from central to obstructive sleep apnea was also observed. Beneficial effects of CRT were noted for subjective sleep parameters and depression level. Significant changes weren’t demonstrated for arterial stiffness. Negative correlations between changes of polysomnographic parameters, subjective sleep parameters and depression intensity with changes of BRS and LVEF were affirmed. The clinical improvement defined as an improvement by at least one NYHA class was connected with an improvement in polysomnographic parameters and subjective parameters evaluating sleep quality, daytime sleepiness and depression level, as well as with an improvement in the autonomic nervous system function and arterial stiffness.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.


Danuta Czarnecka

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tylko w bibliotece

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Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

Jun 26, 2019

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Feb 1, 2016

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Edition name Date
ZB-123739 Jun 26, 2019


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