Title:

Diagnostic ability of serum UM in identifying individual stages of CKD

Author:

Fugiel, Andrzej

Subject:

laboratory diagnosis of CKD ; uromodulin ; stages of CKD ; biomarkers of renal function

Abstract:

The aim of this study was to confirm the existence of a link between the concentration in the blood serum of UM and the prevalence of CKD. The study group included adult patients with CKD stage I-N. The association between serum concentrations of UM, and serum creatinine, cystatin C, and the values of all available data calculated from eGFR formulas was analyzed. The relationship between the serum concentration of UM and biochemical markers of inflammation, calcium-phosphate, malnutrition, peripheral blood counts and NTproBNP was also analyzed. Serum UM decreases with progressive loss of kidney function; this is significantly and negatively correlated with the concentration of creatinine and cystatin C and positively correlated with all applied variables in the analysis models for estimating GFR. The analysis showed that the relationship between UM concentration and eGFR remains independent of key demographics. Based on the results of research and statistical analysis it is proposed to recognize the serum concentration of UM as a new biomarker for assessing renal function.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

nefrologia

Degree grantor:

Wydział Lekarski

Promoter:

Kuźniewski, Marek

Date:

2015

Date issued:

2015

Type:

Praca doktorska

Call number:

ZB-123664

Language:

pol

Access rights:

nieograniczony