Urinary neutrophil gelatinase associated lipocalin (NGAL) as the early biomarker of diabetic kidney disease in the course of diabetes mellitus type 2 - Digital Medical Library

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Title: Urinary neutrophil gelatinase associated lipocalin (NGAL) as the early biomarker of diabetic kidney disease in the course of diabetes mellitus type 2

Author:

Gala-Błądzińska, Agnieszka

Date:

Type:

Praca doktorska

Abstract:

The study evaluates the role of measurements of neutrophil gelatinase-associated lipocalin (NGAL), and albumine and NGAL to creatine (UACR, uNGAL/uCr) markers obtained in the morning urine sample in early diagnosis of diabetic kidney disease (DKD).The study comprises 55 Type 2 diabetic patients (DM t2) aged 18 and over. The data were compared against a group of 22 non-diabetic individuals. Statistically, uNGAL/uCr is much higher in the DM t2 group. uNGAL/uCr and UACR is significantly higher in women and patients with DM t2 and cardiovascular complications. In the DM t2 group, the patient’s age and HbA1c are independent predictive factors for the concentration of uNGAL and uNGAL/uCr. uNGAL and uNGAL/uCr are clinically useful, early, changing dynamically in time, non-invasive DKD indicators, specific for renal tubule damage. The RAA blockade and statin treatment have no influence on the functioning of kidney tubules in DM t2 assessed by uNGAL and uNGAL/uCr.Leucocyturia limits the utility of uNGAL in DKD diagnosis.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia ; nefrologia

Degree grantor:

Wydział Lekarski

Promoter:

Kuźniewski, Marek

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:3984

Call number:

Language:

Access rights:

Subject and keywords:

CChN DM t2 NGAL

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Jun 26, 2023

In our library since:

May 12, 2015

Number of object content hits:

670

Number of object content views in PDF format

82

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3984

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Edition name	Date
ZB-122584	Jun 26, 2023

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