Evaluation of the allergenic potential of propolis inhumans and experimental animals


Basista-Sołtys, Katarzyna


propolis ; the guinea pigmaximization test ; occupational allergy in beekeepers ; allergic contact dermatitis ; balsam of Peru


The questionnaire study among Polish beekeepers hasshown that the percentage of beekeepers that are allergicto propolis is 3.05%. Beekeepers are more likely todevelop allergies to propolis than healthy population(0.64% -1.3%), while they are not more likely to developallergies to propolis than dermatological patients treatedearly because of allergic dermatoses (1.2% - 6.7%). Only14 out of 2205 beekeepers family members usingpropolis as therapeutic agent, reported on propolisallergy. In addition, the study found a strong correlationbetween the prevalence of atopic dermatitis and allergy topropolis. According to this study 3 out of 4 beekeeperswith atopic dermatitis were allergic to propolis. In thegroup of beekeepers with skin dermatoses allergic topropolis was found in 28.9%, while in the group of nonallergicbeekeepers allergy to propolis was reported by0.97%. An animal study showed no sensitizing propertiesof propolis in the guinea pig maximization test (GPMT)at a concentration of 5%. In the studied parts of theanimals’ skins also no inflammatory changes were seenand only the mobilization of granulocytes, mostly withinthe dermis can be observed. However, in the GPMTallergic property of balsam of Peru used in the sameconcentration as propolis was demonstrated, which wasalso confirmed by histopathology study and by elevatedeosinophils level. The skin of the animals from thecontr ; ol group did not indicate changes within theepidermis and the isolated granulocytes were observedonly in the dermis. The results of this animal experimentdid not confirm the strong allergenic properties ofpropolis observed in earlier studies.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

alergologia ; farmakologia

Degree grantor:

Wydział Farmaceutyczny


Filipek, Barbara



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