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Tytuł: Prevalence of inherited thrombophilia polymorphisms among women with recurrent pregnancy loss
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Background. Inherited thrombophilia might lead to recurrent pregnancy loss (RPL).Aim. The aim of this study was to estimate the prevalence of polymorphisms related with inherited thrombophilia among women with RPL in Malopolska region.Material and methods. Group of 136 women, who experienced at least 2 unexplained recurrent pregnancy loss, other possible causes of miscarriage were excluded. 106 healthy women having at least one uncomplicated pregnancy and delivery healthy children constituted a control group. Each patient were examined for: factor V Leiden (FVL), mutation M385T of factor V gene, mutation G2021A and A19911C of prothrombin gene, and C667T and A1298C of 5,10-methylenetetrahydrofoliate reductase gene (MTHFR).Results. Among patients with RPL inhabiting region of Malopolska compared to control group from occurred higher prevalence of:- FVL and mutation M385T of factor V gene, A19911G of prothrombin gene and A1298C of MTHFR gene,- Mutation A19911G of prothrombin gene in group of patients with RPL below 12 weeks of pregnancy, - Coincidence of polymorphism M385T of factor V gene and FVL in group of early and late RPL. Conclusion. 1/ TC genotype of M385T mutation carriers reveal tendency toward RPL below 7 weeks of pregnancy, 2/ Antithrombotic prophylaxis is not justified in case of mutation C667T MTHFR gene polymorphism carriership, 2/ After occurrence of two or more RP ; L inherited thrombophilia evaluation should be recommended
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Data ostatniej modyfikacji:
20 mar 2023
Data dodania obiektu:
30 maj 2014
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http://dl.cm-uj.krakow.pl:8080/publication/3910
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| Nazwa wydania | Data |
|---|---|
| ZB-120652 | 20 mar 2023 |
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