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Tytuł: Endothelial function in atrial fibrillation

Autor:

Rewiuk, Krzysztof

Data:

2014

Typ:

Praca doktorska

Abstrakt:

Introduction: The risk of thromboembolic events in atrial fibrillation (AF) is partially independent of the arrhythmia itself. Endothelial dysfunction could be a pathogenic factor of this phenomenon.Method: The study included 60 patients with recent onset AF (up to 48h), candidates for pharmacological cardioversion. Patients underwent bFMD examination and markers associated with endothelial function (vWF, sE-selectin, ADMA, SDMA, OPG, PTX3, TRAIL, hsCRP) were determined. Patients were re-examined after 7-10 days, using the same assay.Results: The biochemical markers indicated vascular endothelial dysfunction and were partially associated with the presence of co-morbidities. The persistance of atrial fibrillation was associated with a significant decrease in the bFMD while cardioversion to sinus rhythm was not connected with improvement of this parameter. Test markers were not predictors of sinus rhythm return, but allow to predict the presence of the indications for anticoagulation.Conclusions: Patients with acute onset AF are characterized by endothelial dysfunction. The longer duration of arrhythmia leading to further deterioration of endothelial function while the successful cardioversion does not bring the improvement in the short term. The parameters of endothelial function may help to identification of patients with indications for chronic anticoagulation.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

choroby układu krążenia

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Grodzicki, Tomasz

Data wydania:

2013

Identyfikator:

oai:dl.cm-uj.krakow.pl:3896

Sygnatura:

ZB-120486

Język:

pol

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

atrial fibrillation FMD endothelium

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

26 cze 2023

Data dodania obiektu:

15 maj 2014

Liczba wyświetleń treści obiektu:

479

Liczba wyświetleń treści obiektu w formacie PDF

182

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/3896

Wyświetl opis w formacie RDF:

RDF

Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-120486 26 cze 2023

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Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

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12 658 72 56
517 385 669

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Oddział Gromadzenia i Opracowania Zbiorów
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