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Pastuszczak, Maciej
2014
Praca doktorska
Neurosyphilis may occur at every stage of syphilis. When untreated, may progress in a hidden manner for many years, leading to late neurological and psychiatric complications, which may result in permanent disability. The aim of the current study was to assess the immune response in early syphilis by measuring the levels of cytokines typical for innate immune response (TNF-α, IL-1β), Th1, Th2, Th17 and antinflammatory responses (IFN-γ, IL-4, IL-17A, IL-10, TGF-β, respectively) in cerebrospinal fluid (CSF) and serum of syphilitic patients. Significantly higher levels of CSF IFN-α, IL-17A, TNF-α, IL-10 and TGF-β were found in patients with neurosyphilis when compared to those with syphilis but not neurosyphilis. Moreover, in patients with neurosyphilis the relative advantage of antinflammatory response in CSF was found. It may cause adequate conditions for the survival of bacteria and chronic infection.
Kraków
2 - studia doktoranckie
choroby zakaźne
Wydział Lekarski
Wojas-Pelc, Anna
2013
oai:dl.cm-uj.krakow.pl:3681
ZB-120493
pol
nieograniczony
26 cze 2023
18 kwi 2014
679
115
http://dl.cm-uj.krakow.pl:8080/publication/3681
RDF
OAI-PMH
Kotlarz, Agnieszka
Maryńczak, Laura
Broniowska, Żaneta
Styl cytowania: chicago-author-date iso690-author-date
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