Metadane Lista plików Język metadanych English Polski Tytuł: Selected parameters of cell-mediated immune response in syphilis, with special respect to neurosyphilis Autor: Pastuszczak, Maciej Temat i słowa kluczowe: syphilis ; nervous system ; immunology Abstrakt: Neurosyphilis may occur at every stage of syphilis. When untreated, may progress in a hidden manner for many years, leading to late neurological and psychiatric complications, which may result in permanent disability. The aim of the current study was to assess the immune response in early syphilis by measuring the levels of cytokines typical for innate immune response (TNF-α, IL-1β), Th1, Th2, Th17 and antinflammatory responses (IFN-γ, IL-4, IL-17A, IL-10, TGF-β, respectively) in cerebrospinal fluid (CSF) and serum of syphilitic patients. Significantly higher levels of CSF IFN-α, IL-17A, TNF-α, IL-10 and TGF-β were found in patients with neurosyphilis when compared to those with syphilis but not neurosyphilis. Moreover, in patients with neurosyphilis the relative advantage of antinflammatory response in CSF was found. It may cause adequate conditions for the survival of bacteria and chronic infection. Miejsce wydania: Kraków Stopień studiów: 2 - studia doktoranckie Dyscyplina: choroby zakaźne Instytucja nadająca tytuł: Wydział Lekarski Promotor: Wojas-Pelc, Anna Data: 2014 Data wydania: 2013 Typ: Praca doktorska Sygnatura: ZB-120493 Język: pol Prawa dostępu: nieograniczony