Metadata Files list Metadata language English Polski Title: Selected parameters of cell-mediated immune response in syphilis, with special respect to neurosyphilis Author: Pastuszczak, Maciej Subject: syphilis ; nervous system ; immunology Abstract: Neurosyphilis may occur at every stage of syphilis. When untreated, may progress in a hidden manner for many years, leading to late neurological and psychiatric complications, which may result in permanent disability. The aim of the current study was to assess the immune response in early syphilis by measuring the levels of cytokines typical for innate immune response (TNF-α, IL-1β), Th1, Th2, Th17 and antinflammatory responses (IFN-γ, IL-4, IL-17A, IL-10, TGF-β, respectively) in cerebrospinal fluid (CSF) and serum of syphilitic patients. Significantly higher levels of CSF IFN-α, IL-17A, TNF-α, IL-10 and TGF-β were found in patients with neurosyphilis when compared to those with syphilis but not neurosyphilis. Moreover, in patients with neurosyphilis the relative advantage of antinflammatory response in CSF was found. It may cause adequate conditions for the survival of bacteria and chronic infection. Place of publishing: Kraków Level of degree: 2 - studia doktoranckie Degree discipline: choroby zakaźne Degree grantor: Wydział Lekarski Promoter: Wojas-Pelc, Anna Date: 2014 Date issued: 2013 Type: Praca doktorska Call number: ZB-120493 Language: pol Access rights: nieograniczony