Influence of regular interval aerobic training on arterial stiffness and endothelial function in patients with arterial hypertension - Digital Medical Library

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Title: Influence of regular interval aerobic training on arterial stiffness and endothelial function in patients with arterial hypertension

Author:

Kameczura, Tomasz.

Date:

Type:

Praca doktorska

Abstract:

Study group consisted of 60 hypertensive subjects (30 males, 30 females) (age 54,45±8,52 years) previously treated for at least 2 years, with well controlled hypertension, i.e. below 140/90 mmHg, using combined hypertensive therapy. Treatment has not been changed during study period. Study group was randomly subdivided into 2 subgroups. In the first group (G1) AIT was applied for 5 months (40 professional AIT sessions performed two times per week, for 50 minutes each time) accordingly to specially developed program. In the second, control group (G2) there were no training sessions, only medical advice to maintain physical activity accordingly to JNC hypertension guidelines. At the baseline visit and then after five months (final visit), in both groups office BP, PWV and applanation tonometry indexes using SphygmoCor® device and Complior® device were obtained, as well as plasma high selective C-reactive protein (hsCRP), asymetric dimethylarginine (ADMA) and albuminuria in the daily collection (ALB).Results: At the baseline visit there were no significant differences between G1 and G2 groups in the age, office SBP, DBP, PWV, applanation tonometry indexes, hsCRP and ALB. After five months of regular AIT in G1 office SBP (132,8±6,1 mmHg vs. 128,9 ±5,9 mmHg, p<0,05), DBP (80,5±4,1 mmHg vs. 77,8±2,3 mmHg, p<0,05), PWVComplior® (10,3±1,18 m/s vs. 9,26±1,11 m/s, p<0,05), PWVSphygmoCor® (8,37±1,03 mmHg vs. 7,48±0,97 mmHg, p<0.05). Moreover we noticed significant changes in applanation tonometry indexes, such as: central SBP, centaral PP, central and peripheral AIx (all p<0,05) and ADMA concentration in examined group on W2 visit. No significant changes were observed in G2 after AIT in plasma hsCRP concentration and urine ALB. In G2 group SBP, DBP, applanation tonometry indexes, PWV, hsCRP, ALB hasn’t changed between baseline and final visit.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Date issued:

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3677

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Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

physical training arterial hypertension

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Jun 26, 2019

In our library since:

Apr 18, 2014

Number of object content hits:

465

Number of object content views in PDF format

462

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3677

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Edition name	Date
ZB-120496	Jun 26, 2019

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