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Title: Impact assessment of therapeutic intervention during complex percutaneous coronary intervention in acute myocardial infarction with persistent ST-segment elevation on the results and selected left ventricular parameters


STEMI is a clinical problem in terms of selecting the optimal method of treatment and periprocedural proceedings. Thrombectomy as well as inh. gp 2b/3a are the methods for improving coronary perfusion and reducing myocardial injury. Previous studies, incl. 16 RCT, are different in terms of impact on LV function and late outcomes. The purpose of study is the evaluation of the impact of different pPCI strategies on the results of selected LV parameters and confirmation that a specific periprocedural intervention has an influence on long-term outcome. The prospective, randomized study involved 60 STEMI patients with ischemia lasting less than <12 h. Demographic factors as well as risk factors, ST resolution, size of enzymatic damage and angiographic parameters (TIMI,TMPG) were assessed. Transthoracal echocardiography and magnetic resonance imaging was performed at two time points: 3-5 days and at 6 m. after STEMI. Clinical observation involved the hospital period, 6 m. and 71±4 m. follow-up . Direct stenting was significantly more frequent in the aspiration groups. Thromboaspiration in STEMI was associated with comparable angiographic results and intermediate myocardial perfusion markers compared to conventional PCI with abciximab. After thromboaspiration, based on CMR, there was a significant reduction of irreversible components (MVO) in MI zone as well as lower LV remodeling aft ; er 6m. The different periprocedural proceeding didn’t affect the long outcomes, although the trend towards less frequent composite endpoint because of the lower number of cardiac hospitalizations in the conventionally treated group.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

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Wydział Lekarski


Żmudka, Krzysztof

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tylko w bibliotece

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Last modified:

Mar 20, 2023

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Jan 9, 2014

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Edition name Date
ZB-119476 Mar 20, 2023




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