Advanced search ?

Object

Title: The importance of changes in expression and polymorphisms of WT1gene in children with acute myeloid leukemia.

Author:

Stożek, Karol.

Date:

2012

Type:

Praca doktorska

Abstract:

Acute Myeloid Leukemia (AML) is associated with 10-15% of allmalignant tumors of the hematopoietic system in children. Its majorcharacteristics include uncontrolled growth of immature white bloodcells (excluding lymphocytes), erythroblasts and megakaryoblasts.Generally, current treatment strategies lead to complete remission ofthe neoplasm in about 75% of cases, though for AML sucha remission is observed only in ~50% of children. Experiments andanalyses conducted within this study focused mainly on the presenceof the most frequently occurring genetic markers of the disease(Internal Tandem Duplications, ITD within the FLT3 gene) orpotential markers for minimal residual disease (MRD); these includedpresence of pathological mRNA transcripts arising from chromosomalrearrangements (i.e. AML1-ETO [t(8;21)], PML-RARα [t(15;17)] andCBFβ-MYH11 [inv16]). Special consideration was given to alterationsin the WT1 gene expression levels and polymorphisms within theWT1 gene. Current study included 69 children (53.1%) aged 0.2-18.5years (median of 11.2 years), selected from the primary AML group(n=130; admission time: 01.03.2006-31.06.2009; from 14 PPLLSGcenters). Bone marrow and/or peripheral blood samples were collectedfrom each subject at least one year before the commencement of thetreatment. All patients were treated according to AML-BFMINTERIM 2004 programme.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

hematologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Walentyna Balwierz

Date issued:

2012

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3615

Call number:

ZB-118271

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

AML children WT1 gene overexpression polymorphism

Object collections:

Last modified:

Oct 30, 2019

In our library since:

Jul 19, 2013

Number of object content hits:

917

Number of object content views in PDF format

917

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3615

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-118271 Oct 30, 2019

Objects

Similar

The importance of changes in expression and polymorphisms of WT1gene in children with acute myeloid leukemia.

Stożek, Karol.

2012
Praca doktorska

Assessment of selected molecular markers for determination of minimal residual disease in children with acute myeloid leukemia

Książek, Teofila

2016
Praca doktorska

Follow-up of minimal residual disease in acute leukemia patients by monitoring of WT1 expression level by RQ-PCR

Nowakowska-Kopera, Alicja

2008
Praca doktorska

The search for mutations and polymorphisms in the genes formonogenic diabetes among patients with a clinical diagnosis of type 2and type 1 diabetes mellitus

Grzanka, Małgorzata

2014
Praca doktorska

The link between adiponectin gene polymorphisms and selected metabolic syndrome phenotypes

Szopa, Magdalena

2008
Praca doktorska

The assessment of the influence of selected genes' polymorphisms of the renin-angiotensin system, the nitric oxide synthase and the rs7579169 polymorphism of the INHBB gene on the course of pre-eclampsia and gestational hypertension and the condition of newborns

Kuśmierska-Urban, Katarzyna.

2013
Praca doktorska

The influence of the selected polymorphisms of the paraoxonase genes on the risk of sporadic Alzheimer’s disease in a Polish population and on the response to treatment of Alzheimer’s disease with acetylocholinesterase inhibitors

Marona, Monika

2010
Praca doktorska

Disordered calcium - phosphate homeostasis and nutritional status in children with newly diagnosed inflammatory bowel disease

Świat, Agnieszka

2012
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information