Obiekt
Tytuł: Optimalization of anti-ischemic therapy in patients with non ST- segment elevation myocardial infraction
Abstrakt:
Non ST-segment elevation acute coronary syndromes (NSTE ACS) are the major cause of hospitalization of patients with coronary artery disease (CAD). Despite improvement of treatment the short-term prognosis and long-term outcome of those patients remain poor. The administration of glycoprotein GP IIb/IIIa blockers has shown beneficial in recent clinical trials both in conservatively treated patients and after percutaneous coronary interventions (PCI). Another option for use of GP IIb/IIIa blockers with unfractionated heparin are direct thrombin inhibitiors with widely used bivalirudin. The aim of this trial was to compare the efficacy and safety of different anti-thrombotic regimens in treatment of troponin-positive NSTE ACS. One hundred patients enrolled in the trial were randomized to two treatment arms: integrillin (GP IIb/IIIa blocker) with unfractionated heparin or bivalirudin. We found statistically significant difference in the size of the infarct evaluated with enzymatic curves in favour of GP IIb/IIIa inhibitor + unfractionated heparin group. There were no differences between two groups in coronary flow after PCI in TIMI scale in infarct-related artery and the incidence of bleeding complications. The combined end-point of death, stroke, repeated myocardial infarction and bleeding complications occurred with no significant difference between the group during in-hospital, ; one month and six months follow-up period.
Miejsce wydania:
Stopień studiów:
Dyscyplina:
Instytucja nadająca tytuł:
Promotor:
Data wydania:
Identyfikator:
Sygnatura:
Język:
Prawa dostępu:
Kolekcje, do których przypisany jest obiekt:
Data ostatniej modyfikacji:
17 mar 2023
Data dodania obiektu:
19 lip 2013
Liczba wyświetleń treści obiektu:
20
Liczba wyświetleń treści obiektu w formacie PDF
0
Wszystkie dostępne wersje tego obiektu:
http://dl.cm-uj.krakow.pl:8080/publication/3614
Wyświetl opis w formacie RDF:
Wyświetl opis w formacie OAI-PMH:
| Nazwa wydania | Data |
|---|---|
| ZB-118303 | 17 mar 2023 |
Obiekty
Podobne
Chyrchel, Bernadeta
Zorkun, Cafer Sadik
