Advanced search ?

Object

Access Limited

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: Investigation of mechanisms of the anti-atherosclerotic effect of agmatine in apoE knockout mice

Author:

Wiśniewska, Anna

Date:

2013

Type:

Praca doktorska

Abstract:

Agmatine is an endogenous polyamine produced by decarboxylation of L-arginine and exerts a wide array of biologic effects. It has been shown that agmatine has anti-inflammatory function, inhibits the proliferation of smooth muscle cells, protects the mitochondria and modulates fatty acid metabolism. These properties of agmatine makes it an interesting candidate for anti-atherosclerotic compound. The aim of the study was to investigate the effect of exogenous agmatine on the development of atherosclerosis in apoE-knockout mice and identify the most probable mechanism responsible for anti-atherosclerotic action of agmatine.The research was carried out on male apoE-knockout mice at the age of 8 weeks. Animals was divided into two groups: control group (on chow diet, n=10) and treatment group (on chow diet mixed with agmatine, dose 20 mg per kg of body weight per day, n=8). Both methods en face and cross section showed that agmatine by 40% inhibited formation of atherosclerotic plaques. Immunohistochemistry showed that agmatine may increase plaque stability by decreasing number of macrophages. What’s more, action of agmatine was associated with increase of the high density lipoproteins (HDL) in blood. Real-Time PCR analysis showed that modulates the oxidation of fatty acid and cholesterol biosynthesis. Widespread mitochondrial action of this drug has been demonstrated by proteomic methods as well.We are tempted to speculate that in the future, compounds with similar mechanism of action could represent new group of drugs for prevention and/or treatment of atherosclerosis and coronary heart disease.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Rafał Olszanecki

Date issued:

2012

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3598

Call number:

ZB-118578

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

atherosclerosis agmatine apoE-knockout mice mitochondria lipid metabolism

Object collections:

Last modified:

Jul 15, 2019

In our library since:

Jul 18, 2013

Number of object content hits:

25

Number of object content views in PDF format

8

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3598

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-118578 Jul 15, 2019

Objects

Similar

Investigation of mechanisms of the anti-atherosclerotic effect of agmatine in apoE knockout mice

Wiśniewska, Anna

2013
Praca doktorska

Influence of new biocompatible, cationic polysaccharides on lipid metabolism in laboratory animals - efforts of determination of action mechanism

Stefan, Joanna

2015
Praca doktorska

In vitro and in vivo effects of inorganic air pollutants on the development of atherosclerosis and hepatic steatosis

Stachyra, Kamila

2023
Praca doktorska

The potential antiatherogenic effect of angiotensin 1-7 receptor pharmacological regulation

Totoń-Żurańska, Justyna

2012
Praca doktorska

The potential antiatherogenic effect of doxycycline –nonselective inhibitor of matrix metalloproteinases - on experimental model of atherosclerosis – apoE-knockout mice

Pawłowska, Małgorzata

2011
Praca doktorska

The role of the fatty acid receptor FFAR4 in the inhibition of atherosclerosis and nonalcoholic fatty liver disease

Kiepura, Anna

2023
Praca doktorska

Liver and kidney mitochondria proteome changes inatherosclerosis in apoE-knockout mice model

Suski, Maciej

2012
Praca doktorska

The influence of metabolic stress factors and quercetin on mitochondrial function ofpreadipocytes

Dziewońska, Agnieszka

2013
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information