The aim of the study was to test whether preoperative lornoxicam administration (preemptive analgesia) in lower third molar surgery may affect the development of the sensitization process in the perioperative period. The study examined whether 16 mg of lornoxicam administered orally 60 min. before surgical extraction (group A) provides effective postsurgical analgesia and reduces the total rescue analgesic intake, compared with 16 mg of lornoxicam administered orally 60 min. after surgery (group B), and a placebo (group C).During the 24 hours after surgery, 90 patients were asked to complete a VAS, NRS and MPQ that assessed their pain level and were asked to note each episode of pain that forced them to use paracetamol as well as note the total amount of paracetamol intake.Conclusions:1) preemptive use of lornoxicam in third molar surgery does not inhibit the activation of the sensitization process connected with phase I of the nociceptive information flow;2) 16 mg of lornoxicam administered 60 min. before surgical extraction does not significantly reduce the pain intensity, delay the onset of pain, or lower the total rescue analgesic intake in the postoperative period in comparisonwith 16 mg of lornoxicam administered 60 min. after surgical extraction;3) 16 mg of lornoxicam administered 60 min. before or after surgical extraction significantly reduces the pain intensity, delays the onset of pain, and lowers the total rescue analgesic intake in the postoperative period in comparison with the placebo.
Nov 8, 2019
Jul 18, 2013
|Z-118533||Nov 8, 2019|
Kościelniak-Merak, Barbara Karolina